Anti-tumoral effect of GTN in a chemo-induced inflammatory microenvironment - LIIC

Anti-tumoral effect of GTN in a chemo-induced inflammatory microenvironment

Anti-tumoral effect of GTN in an chemo-induced inflammatory microenvironment Anti-tumoral effect of GTN in an chemo-induced inflammatory microenvironment

The purpose of this research axis is to study the anti-tumor effect of GTN in a chemo-induced inflammatory microenvironment by:

  • Investigating the effects of platinum derivatives on the production of pro-inflammatory cytokines in cancer cells,
  • Studying the  antitumor effect of GTN in combination with platinum derivatives:
    • Set up of optimal combination conditions to inhibit tumor growth in mouse models,
    • Analysis of the role of immune cells in the antitumor response,
    • Determination of the mode of action of  GTN harnessing inflammatory components to favor an antitumor response.
  • Targeting inflammatory components that may predict the antitumor effect of GTN in human tumors (after neo-adjuvant, platinum-based chemotherapy treatment).